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Exploration of the application of spray drying technology in the development of new drugs

Spray drying technology is a key technology that is widely used in the development of new drugs. By ejecting drug formulations in the form of very fine sprays into a stream of hot air, the technology enables rapid drying of drug particles, resulting in rapid drug preparation and improved stability. The following are the main applications and advantages of this technology in new drug development.

January 23, 2024

Spray drying technology is a key technology that is widely used in the development of new drugs. By ejecting drug formulations in the form of very fine sprays into a stream of hot air, the technology enables rapid drying of drug particles, resulting in rapid drug preparation and improved stability. The following are the main applications and advantages of this technology in new drug development.


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Spray drying technology: optimizing drug solubility and bioavailability

Spray drying technology plays an important role in the development of new drugs, mainly for the preparation of solid dispersions. Since the bioavailability of many drugs is limited by their solubility, the use of this technique allows the preparation of drug particles into microfine particles, which improves their solubility and increases their absorption in the human body. In addition, solid dispersions can be formed by incorporating carriers or coating agents to enhance drug stability, and controllability, and prolong release time.

spray dryer             

Spray drying technology: preparation of nano-dispersions for targeted delivery and controlled release effects

In addition to the preparation of solid dispersions, spray drying technology can also be used to prepare nanodispersions. In recent years, nanotechnology has been widely used in the field of drug discovery and development. Nanoparticles have a larger specific surface area and better bioavailability than conventional particles, which are advantageous in achieving better-targeted delivery and controlled release of drugs. By controlling the spray particle size and solvent properties, spray drying technology can prepare nanoscale particles, providing strong support for targeted delivery and controlled release of drugs.
spray dryer            

Spray Drying Technology: Improving Drug Stability and Reducing Degradation Risks

In new drug development, drug stability is critical. Photosensitive and heat-sensitive drugs are often susceptible to degradation and inactivation by light and heat. Spray drying technology can prepare dry powder forms with no or low water content, thus reducing contact with water and improving stability. In addition, the formation of stabilized drug particles by the addition of protective or coating agents is also an advantage of this technology, further protecting the active ingredients of the drug.
           


Spray Drying: Efficient Preparation of Various Pharmaceutical Formulations

Spray drying technology is characterized by high-efficiency preparation and scalability. Its equipment process is simple, easy to operate, and can realize continuous production, thus improving the preparation efficiency. In addition, the technology applies to a wide range of pharmaceutical dosage forms, including solid particles, emulsions, suspensions, and films, and is widely scalable and applicable.

spray dryer

           

As an important new drug development technology, spray drying technology improves the bioavailability and solubility of drugs, protects the active ingredients, and enhances stability. It strongly supports new drug development and plays an important role in clinical applications.


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